Forebrain GABAergic projections to locus coeruleus in mouse
نویسندگان
چکیده
منابع مشابه
Organization of hypocretin/orexin efferents to locus coeruleus and basal forebrain arousal-related structures.
Hypocretin/orexin neurons give rise to an extensive projection system, portions of which innervate multiple regions associated with the regulation of behavioral state. These regions include the locus coeruleus, medial septal area, medial preoptic area, and substantia innominata. Evidence indicates that hypocretin modulates behavioral state via actions within each of these terminal fields. To un...
متن کاملHeterogeneous organization of the locus coeruleus projections to prefrontal and motor cortices.
The brainstem nucleus locus coeruleus (LC) is the primary source of norepinephrine (NE) to the mammalian neocortex. It is believed to operate as a homogeneous syncytium of transmitter-specific cells that regulate brain function and behavior via an extensive network of axonal projections and global transmitter-mediated modulatory influences on a diverse assembly of neural targets within the CNS....
متن کاملLocus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior
Increased tonic activity of locus coeruleus noradrenergic (LC-NE) neurons induces anxiety-like and aversive behavior. While some information is known about the afferent circuitry that endogenously drives this neural activity and behavior, the downstream receptors and anatomical projections that mediate these acute risk aversive behavioral states via the LC-NE system remain unresolved. Here we u...
متن کاملIdentification of a Group of GABAergic Neurons in the Dorsomedial Area of the Locus Coeruleus
The locus coeruleus (LC)-norepinephrine (NE) system in the brainstem plays a critical role in a variety of behaviors is an important target of pharmacological intervention to several neurological disorders. Although GABA is the major inhibitory neurotransmitter of LC neurons, the modulation of LC neuronal firing activity by local GABAergic interneurons remains poorly understood with respect to ...
متن کاملGABAergic synaptic inputs of locus coeruleus neurons in wild-type and Mecp2-null mice.
Rett syndrome is an autism spectrum disorder resulting from defects in the gene encoding the methyl-CpG-binding protein 2 (MeCP2). Deficiency of the Mecp2 gene causes abnormalities in several systems in the brain, especially the norepinephrinergic and GABAergic systems. The norepinephrinergic neurons in the locus coeruleus (LC) modulate a variety of neurons and play an important role in multipl...
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ژورنال
عنوان ژورنال: Journal of Comparative Neurology
سال: 2013
ISSN: 0021-9967
DOI: 10.1002/cne.23291